Non-gynaecological Cytology
Liver cytology
Anatomy and histology of the liver
Fine needle aspiration (FNA)
Normal cells
Infections
Benign lesions
Malignant tumors

Liver cell adenoma

It is an uncommon benign tumor, usually occurring in women under the age of 30 who have a history of use of oral contraceptives. Histologically, they are only composed of hepatocytes.

Cytologic diagnostic features

  • Predominance of hepatocytes
  • Mild nuclear atypia
  • Abundant cytoplasm
  • Normal N/C ratio

Differential diagnosis

  • Normal liver
  • Focal nodular hyperplasia
  • Regenerating nodules in cirrhosis
  • Hepatocellular carcinoma

It has been suggested that the absence of bile duct epithelium supports a diagnosis of hepatic adenoma excluding focal nodular hyperplasia. The cells of hepatocellular carcinoma have a higher N/C ratio and more nuclear atypia.


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